Semaglutide Injections for Weight Loss
What is Semaglutide?
Recent research shows that injected Semaglutide is a highly effective medication for weight loss.
Anti-obesity medications have been around for decades, and there are several that are currently in use. But Semaglutide is a new generation of highly effective hormone-based obesity medications. Semaglutide mimics a hormone called glucagon-like peptide-1 (GLP-1), which is secreted in the gut and targets receptors throughout the body, including the brain. When a person is eating, GLP-1 sends the brain the “I’m full” signal.
Semaglutide also decreases “gastric emptying,” the process by which stomach contents are moved into the first part of the small intestine as part of the digestive process. This effect decreases over time, however the action of sending the "I'm full" signal is why Semaglutide works over long periods of time.
The action of making people feel full means people generally eat smaller portions at meals and do not have the same desire to constantly snack between meals.
Tirzepatide Injections for Weight Loss
What is Tirzepatide?
Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist (RA) that was approved by the FDA for the treatment of type 2 diabetes. The drug is manufactured by Eli Lilly & Co. under the brand name Mounjaro™ and was approved in May 2022.
Historically, the treatment of obesity focused almost exclusively on lifestyle-based approaches. However, evidence that diet and exercise prompt physiological counterregulatory mechanisms that limit weight reduction and impede weight maintenance has led to the realization that obesity is a complex, multicomponent metabolic disease of energy homeostasis involving central and peripheral mechanisms. Once obesity is present, those mechanisms render a return to lower weight difficult. Accordingly, several clinical guidelines now recommend treatment with antiobesity medications for people with obesity or for those with overweight and weight-related complications. Recent studies with long-acting glucagon-like peptide-1 (GLP-1) receptor agonists demonstrated that greater efficacy with acceptable safety could be achieved by targeting the pathways of endogenous nutrient-stimulated hormones. Glucose-dependent insulinotropic polypeptide (GIP), another nutrient-stimulated hormone, regulates energy balance through cell-surface receptor signaling in the brain and adipose tissue.
How effective is Semaglutide Injections for Weight Loss
In a double blind trial, at the end of 68 weeks, the average weight loss from participants given Semaglutide was 33.7 lbs with a 5.3 inch reduction in waist size.
How effective is Tirzepatide Injections for Weight Loss
In a double blind trial, the mean change in participant weight at week 72 was 52.0 lbs at the 15-mg dose.
40% of participants lost 20% of their body weight after 20 weeks.
As described by a study participant in an article by Yale Medicine:
“It worked for me because my issue is mindlessly overeating. Because the drug often makes me feel incredibly full after just a few bites, it has been a real change to my eating habits,” the participant says. She used to consume 3,000 calories a day “easily,” and in the trial, she has been unable to take in more than 1,500. “One serving of Oreos is three cookies, and it was always a struggle to stop at three,” she says. “In the trial, I found it a real struggle to eat more than three.”
At the weekly dose of 15 mg Tirzepatide
36% of Tirzepatide lost 25 pounds or more
8% of Semaglutide users lost 25 pounds or more.
Over the course of 40 weeks Tirzepatide 5mg, 10mg and 15mg offers at least 30%, 60% and 95% more weight loss versus Semaglutide 1 mg.
How do I receive the Semaglutide or Tirzepatide?
We provide you with all the tools you need to track and monitor your Semaglutide or Tirzepatide injections and progress. Your doctor will help you ramp up to your maintenance dose and be available every step of the way.
Your initial prescription is shipped to our clinic so we can educate you on proper injection and use. All future Semaglutide or Tirzepatide is shipped directly to your home for your convenience. With us, your costs can be 30%-50% less than what a pharmacy may charge you per months supply.
Since you only need to be physically present for the first injection, all other appointments (including the first appointment to evaluate suitability) can be done via telemedicine. This is highly convenient for patients who may not live near the clinic.
Will Semaglutide or Tirzepatide Injections work for me?
Semaglutide and Tirzepatide is not recommended for those with a personal or family history of certain endocrine or thyroid tumors, specifically, medullary thyroid cancer or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Semaglutide and Tirzepatide works best with patients with a BMI > 30. Weight loss injections work best with lifestyle changes. Your physician will consult with you on a program that fits your weight loss goals.
Semaglutide and Tirzepatide does require self administration via subcutaneous injections after the initial dosing. Dr Janel will train you on safe and easy injections.
How to choose between Semaglutide or Tirzepatide?
Tirzepatide outperforms Semaglutide for weight loss at comparable doses. That said, we have had near universal positive success stories with patients using Semaglutide.
There is an option to switch from Semaglutide to Tirzepatide if patients are not getting the results they would like from Semaglutide.
The best way to determine which option for weight loss is best for you is to schedule an appointment with Dr Janel to discuss your treatment options!
* - Please be advised that we are not prescribing Semaglutide or Tirzepatide for treatment of diabetes.